Table 1.
Overview of publications in the disease clusters CNS/PNS and retina, Ischemia and reperfusion and Liver diseases.
| Disease entity | oc | Disease model | Gene manipulation and genetic background | Sex | Ref |
|---|---|---|---|---|---|
| CNS/PNS and retina | |||||
| Retina | - | pruning/glaucoma* | DBA/2J | f/m | (10) |
| + | glaucoma | DBA/2J | f | (11) | |
| + | glaucoma | DBA/2NNia | f/m | (12) | |
| + | glaucoma | DBA/2J | f/m | (13) | |
| = | AMD | rd1 | f/m | (14) | |
| = | AMD | C1q-/-, C1q-/-MBL-/- | f/m | (15) | |
| = | AMD | f/m | (16) | ||
| + | AMD | f/m | (17) | ||
| - | retinal aging | f/m | (18) | ||
| Neuro-degeneration and aging | + | AD | Q-/-, APPQ -/-, APPPS1Q-/-, C57BL/6, B6/SJL | f/m | (2) |
| + | AD | APPQ -/-, APPPS1Q-/-, B6/SJL | f/m | (19) | |
| = | AD | 3xTgBUBC1q-/-, BUB/BnJ | f/m | (20) | |
| + | AD | f/m | (21) | ||
| + | FTLD | Grn-/-;C1q-/- | f/m | (22) | |
| + | FTLD | Grn-/-;C1q-/-, Grn-/-;C1q-/-;C3-/- | f/m | (23) | |
| = | ALS | SOD1G37R/C1q-/- | f/m | (24) | |
| + | ALS | IL-1α-/- TNFα-/- C1q-/- , IL-1α-/- TNFα-/- C1q-/- SOD1G93A | f/m | (25) | |
| = | M. Parkinson | m | (26) | ||
| - | amyloid neuropathy | mTTR-/-hTTRMet30+/+mC1q-/-, 129X1/SvJ/C57BL/6 | f/m | (27) | |
| + | OIBP | f/m | (28) | ||
| + | brain aging | f/m | (29) | ||
| CNS injury | = | TBI | f/m | (30) | |
| + | TBI | C1q-/-, IL-1α-/- Tnf-/- C1q-/- | f/m | (31) | |
| - | TBI | f/m | (32) | ||
| - | TBI | f/m | (33) | ||
| + | TBI | f/m | (34) | ||
| + | injury by radiation | C1qaFL/FL : Cx3cr1CreERT2/WganJ | m | (35) | |
| + | spinal cord injury | BUB/BnJ | m | (36) | |
| = | spinal cord injury | BUB/BnJ | m | (37) | |
| PNS injury | = | peripheral nerve lesion | f | (38) | |
| = | peripheral nerve lesion | f/m | (39) | ||
| Infection | + | prion disease | C1qa-/- , C1qa/H2-Bf/C2-/- | f/m | (3) |
| + | prion disease | f | (4) | ||
| = | prion disease | f/m | (40) | ||
| = | HIV-and HAND | f/m | (41) | ||
| MS | + | MS | f/m | (42) | |
| = | MS | f/m | (43) | ||
| + | MS | C1qfl/fl;TMEM-CreERT/+ | f/m | (44) | |
| Depression | - | depression | m | (45) | |
| Epilepsy | - | epilepsy | f/m | (46) | |
| - | epilepsy | background n.s. | m | (47) | |
| Ischemia and reperfusion | |||||
| H/I | + | H/I stroke | f/m | (5) | |
| + | H/I stroke | f/m | (48) | ||
| Stroke | = | ischemic stroke | f/m | (49) | |
| = | ischemic stroke | m | (50) | ||
| + | ischemic stroke | C1q/MBL-/- | m | (51) | |
| I/R | + | retinal I/R | f/m | (52) | |
| = | GI I/R | m | (53) | ||
| = | GI I/R | f/m | (54) | ||
| + | GI I/R | f/m | (55) | ||
| + | myocardial I/R | C1q-/-, C1q/fD-/- | m | (56) | |
| + | skeletal muscle I/R | f/m | (57) | ||
| = | cutaneous I/R | m | (58) | ||
| Liver diseases | |||||
| Liver toxicity | + | ALD | f | (59) | |
| + | ALD | C1qa-/- , C1qa/FD-/- | f | (60) | |
| + | hepatotoxicity | m | (61) | ||
| = | hepatotoxicity | f | (62) | ||
| + | NASH | m | (63) | ||
Each cluster is subdivided according to disease and organ manifestation, respectively. Disease outcome (oc) of C1qKO mice compared to wt and/or C1q sufficient mice in the investigated disease model is given as “+” respectively turquoise =beneficial, “-” respectively ocher =detrimental, “=“ respectively grey=no effect. The overall outcome on the disease entity is similarly color coded using lighter shades for ambiguous group results. Genetic modifications other than C1qKO and genetic background other than C57BL/6 are listed explicitly. In studies with several C1q deficient mice, all C1q deficient mice are listed. Sex as indicated in the study (f=female only, m=male only, f/m=mixed gender); if not mentioned explicitly by the study, mixed gender was assumed. AD, Alzheimer’s disease; ALD, alcoholic liver disease; ALS, amyotrophic lateral sclerosis; AMD, age-related macular degeneration; APP, amyloid precursor protein; FLTD, frontotemporal lobar degeneration; GI I/R, gastrointestinal ischemia/reperfusion; H/I, hypoxia/ischemia; HAND HIV, associated neurocognitive disorder; I/R, Ischemia/reperfusion; MS, multiple sclerosis; NASH, non-alcoholic steatohepatitis; n.s., not specified; OIBP, obesity induced brain pathology; PNS, peripheral nervous system; TBI, traumatic brain injury. *in the Glaucoma part of the study no C1qKO mouse model was used; the outcome classification relates to synapse elimination.