Table 3.
Overview of publications in the disease clusters Vascular diseases, Pregnancy, Cancer and Various.
| Disease entity | oc | Disease model | Gene manipulation and genetic background | Sex | Ref |
|---|---|---|---|---|---|
| Vascular diseases | |||||
| Atherosclerosis | - | atherosclerosis | C1q-/-/Ldlr-/- | f | (125) |
| - | atherosclerosis | C1q.Ldlr-/- , C1q.sIgM.Ldlr-/- | f | (126) | |
| - | woundhealing | – | f/m | (127) | |
| - | ALI | – | f | (128) | |
| - | primary hemostasis | f/m | (129) | ||
| Pregnancy | |||||
| Fetal loss | - | fetal loss | f | (130) | |
| + | fetal loss | C1q/fD -/- | f | (131) | |
| = | fetal loss | f | (132) | ||
| PE | - | PE | f | (133) | |
| - | PE | f | (134) | ||
| - | PE | f | (135) | ||
| Cancer | |||||
| Solid tumor | + | melanoma | f/m | (136) | |
| = | breast cancer | neuT+-C1q-/-, BALB/c | f | (137) | |
| + | ccRCC | f/m | (138) | ||
| Tumor therapy | - | immunotherapy | f/m | (139) | |
| = | immunotherapy | f/m | (140) | ||
| = | immunotherapy | m | (141) | ||
| - | immunotherapy | SCID/C1q-/- | f | (142) | |
| Various | |||||
| Skin | = | burn injury | f/m | (143) | |
| + | epidermolysis bullosa | BALB/c | f/m | (144) | |
| + | muscle regeneration | f/m | (145) | ||
| Pulmo | - | COPD | f | (146) | |
| + | pulmonary fibrosis | f/m | (147) | ||
| = | AA amyloidosis | C57B L 6×129/SV | f/m | (148) | |
| = | adipose inflammation | f | (149) | ||
Each cluster is subdivided according to disease and organ manifestation, respectively. Disease outcome (oc) of C1qKO mice compared to wt and/or C1q sufficient mice in the investigated disease model is given as “+” respectively turquoise =beneficial, “-” respectively ocher =detrimental, “=“ respectively grey=no effect. The overall outcome on the disease entity is similarly color coded using lighter shades for ambiguous group results. Genetic modifications other than C1qKO and genetic background other than C57BL/6 are listed explicitly. In studies with several C1q deficient mice, all C1q deficient mice are listed. Sex as indicated in the study (f=female only, m=male only, f/m=mixed gender); if not mentioned explicitly by the study, mixed gender was assumed. ALI, acute lung injury; AA, amyloid A protein; COPD, chronic obstructive pulmonary disease; PE, preeclampsia.