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. 2022 Aug 18;44(6):2623–2653. doi: 10.1007/s11357-022-00620-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Ganglion cells (possible) in early AMD. Two round-shape cells located in the widened outer collagenous layer of the Bruch’s membrane (pGc). They have round nucleus, narrow cytoplasm which contain some mitochondria, endoplasmic reticula, and lysosomes. Thin basement membrane surrounds both cell bodies. Mitochondria with loss of cristae and matrix-density in the RPE (black arrow), basal linear deposits (white arrow), and BLD can also be seen. ela: elastic layer, cap: capillaries. Seventy-six years; female; ×19,000; bar: 1 μm