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. 2022 Feb 8;122(7):1147–1158. doi: 10.1055/a-1723-1880

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 4 — Platelet viability upon pneumolysin treatment. Platelet viability upon treatment with different pneumolysin (Ply) concentrations ( A–C ) or with pneumolysin (Ply) preincubated with IVIG or trimodulin, respectively. Viability was assessed by real-time measurement of relative luminescence units (RLU) resulting from the enzymatic conversion of a substrate by viable platelets. Curves represent the median of platelets of ≥5 donors. As a control, platelets were incubated with PBS only. For statistical analysis, the measurement endpoints (RLU of the final minute) were compared applying the Friedman test, followed by uncorrected Dunn's test for multiple comparisons. A p -value <0.05 was considered to be significant (* > 0.033, ** > 0.002 , *** > 0.001). IVIG, intravenous immunoglobulin; PBS, phosphate-buffered saline.