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. Author manuscript; available in PMC: 2022 Aug 18.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2021 Oct 14;1869(1):119161. doi: 10.1016/j.bbamcr.2021.119161

Fig. 6.

Fig. 6.

Perinuclear IDR-containing proteins with phase separation ability. (A) Venn diagram (analyzed with BioVenn, available at http://www.biovenn.nl) showing the overlap between predictions by catGRANULE (score ≥ 0.5), PScore (score ≥ 4.0) and perinuclear proteins with peer-reviewed published evidence of phase behavior (in vitro and/or in vivo). (B) STRING network of functional and physical protein-protein interactions. Top: perinuclear LLPS-IDR-containing proteins with 43 members. Bottom: LLPS-IDR-containing proteins with 74 members. Proteins highlighted in cyan are potential hubs using this classification. (C) Combined STRING (only physical interaction shown) and UniProt keywords evaluation of NA-related and cytoskeleton-related processes. Top: LLPS-IDR-containing proteins. Bottom: non-LLPS-IDR-containing proteins. Evidence from literature is assigned with PMID. Legend is shown in the middle.