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. 2022 Jul 5;608(7923):603–608. doi: 10.1038/s41586-022-05053-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Frequencies of BA.1, BA.1.1, BA.2, BA.2.12.1 and BA.4/5 deposited in GISAID. The value in the upper right corner of each box denotes the cumulative number of sequences for all circulating viruses in the denoted time period. b, Unrooted phylogenetic tree of Omicron and its subvariants along with other main SARS-CoV-2 variants. The scale bar indicates the genetic distance. c, Key spike mutations found in BA.2, BA.2.12.1, BA.4 and BA.5. Del, deletion.