Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 5;608(7923):603–608. doi: 10.1038/s41586-022-05053-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, Neutralization of D614G and Omicron subvariants by RBD- and NTD-directed mAbs. Values above the limit of detection of 10 μg ml⁻¹ (dotted line) are arbitrarily plotted to allow for visualization of each sample. b, Fold change in IC₅₀ values of point mutants relative to D614G or BA.2, with resistance coloured red and sensitization coloured green. c, Location of F486V, L452R/Q and R493Q on D614G RBD, with the colour indicating the per residue frequency recognized by SARS-CoV-2 neutralizing antibodies. d,e, Modelling of L452R/Q (d) and F486V (e) affect class 2 mAb neutralization. The clashes are shown with red plates; the hydrogen bonds are shown with dark dashed lines. The results shown in a and b are representative of those obtained in two independent experiments.