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. 2022 Jul 5;608(7923):603–608. doi: 10.1038/s41586-022-05053-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Neutralization of pseudotyped D614G and Omicron subvariants by sera from four different clinical cohorts. b, Fold change in geometric mean ID₅₀ titres of boosted vaccinee sera relative to D614G and BA.2, with resistance coloured red and sensitization coloured green. c, Serum neutralization of BA.2 pseudoviruses containing single mutations found within BA.2.12.1 and BA.4/5. d, Antigenic map based on the neutralization data of boosted vaccinee sera. SARS-CoV-2 variants are shown as coloured circles and sera are shown as grey squares. The x, y and z axis represent antigenic units (AU) with one grid corresponding to a two-old serum dilution of the neutralization titre. An interactive map is available online (https://figshare.com/articles/media/OmicronAntigenicMap/19854046). The map orientation in the x, y and z axis is free to rotate. For all the panels in a and c, values above the symbols denote the geometric mean ID₅₀ values and values on the lower left show the sample size (n) for each group. P values were determined by using two-tailed Wilcoxon matched-pairs signed-rank tests. The results shown are representative of those obtained in two independent experiments.