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. 2022 Jul 5;608(7923):603–608. doi: 10.1038/s41586-022-05053-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Neutralization by a, boosted vaccinee sera on pseudoviruses. b, non-Omicron infection & vaccination sera on pseudoviruses. c, BA.1 breakthrough sera on pseudoviruses. d, BA.2 breakthrough sera on pseudoviruses. e, boosted vaccinee sera on authentic viruses. f, Neutralization ID₅₀ titers of authentic BA.2 and BA.4 by boosted vaccinee sera. Values above the symbols denote the geometric mean ID₅₀ values and values on the lower left show the sample size (n). P values were determined by using two-tailed Wilcoxon matched-pairs signed-rank tests. Error bars in a, b, c, d, and e denote mean ± SEM for three technical replicates. All data are representative of those obtained in two independent experiments.