表 1.
Y染色体无精子症因子c区缺失患者首次及第二、三次同步显微取精术后行卵胞浆内单精子显微注射治疗结局比较
Comparison of intracytoplasmic sperm injection outcomes in azoospermia factor c region deletion patients after the first, second and third synchronous procedure
| Items | First synchronous procedure (n=99) | Second synchronous procedure (n=17) | Third synchronous procedure (n=2) | P(comparison beteeen first and second procedure) | ||
| Fertilization rate = 2 pronucleus zygotes/mature oocytes；High quality embryo rate = number of high quality embryos / number of cleavages；a，P value was calculated using t test；b，P value was calculated using chi-squared test (χ2 test)；c，P value was calculated using Fisher's test. | ||||||
| Age/years | ||||||
| Male, x±s | 31.4±5.1 | 34.1±6.7 | 0.088a | |||
| Female, x±s | 29.8±4.0 | 31.3±4.7 | 0.296a | |||
| Embryonic development | ||||||
| Oocytes retrieved, n, x±s | 15.0±7.4 | 12.9±9.2 | 0.354a | |||
| Mature oocytes, n, x±s | 12.0±6.2 | 10.4±7.4 | 0.592a | |||
| Fertilization rate | 31.6% (377/1 191) | 45.8% (81/177) | 39.3% (11/28) | 0.000b | ||
| Good quality embryo rate | 47.7% (257/539) | 50.4% (61/121) | 43.75% (7/16) | 0.587b | ||
| Embryo transfer | ||||||
| Fresh embryo transfer rate | 53.5% (53/99) | 70.6% (12/17) | 50.0% (1/2) | |||
| No embryo availability rate | 21.2% (21/99) | 11.8% (2/17) | ||||
| Total embryo cryopreservation rate | 25.3% (25/99) | 17.6% (3/17) | 50.0% (1/2) | |||
| Clinical pregnancy rate | ||||||
| Fresh embryos transfer cycle | 40.5% (18/53) | 50.0% (6/12) | 0% (0/1) | 0.299b | ||
| Frozen-thawed embryos transfer cycle | 33.3% (12/36) | 50.0% (3/6) | 100.0% (1/1) | 0.649c | ||
| Miscarriage rate | 6.7% (2/30) | 22.2% (2/9) | 0.223c | |||
| Live birth rate | 28.3% (28/99) | 41.2% (7/17) | 50.0% (1/2) | 0.285b | ||
| Birth defects, n | 0 | 0 | 0 | |||