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. 2022 Jul 27;45(8):513–521. doi: 10.14348/molcells.2022.2056

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Fig. 2 — A historical overview of the understanding of CTLA-4 biology from 1987 to 2021 is provided. ctCTLA-4, Cytoplasmic domain of CTLA-4; GC B, germinal center B cells; Treg cells, regulatory T cells. Diagram created with BioRender (https://biorender.com/).