TABLE 4.

Univariable and multivariable analyses of autoantibody levels at 2nd blood draw predicting DCR and ORR. Multivariable analysis was adjusted for tumor type

Variable	Univariable analysis		Multivariable analysis
	RD (95% CI)	p‐value	RD (95% CI)	p‐value
DCR
Any autoantibody
Negative	1 (reference)		1 (reference)
Positive	−0.214 (−0.538–0.111)	0.197	−0.332 (−0.682–0.017)	0.062
ANA
<1:80 (negative)	1 (reference)		1 (reference)
≥1:80 (positive)	−0.004 (−0.343–0.334)	0.981	0.110 (−0.268–0.489)	0.567
ANA titer change
No increase	1 (reference)		1 (reference)
Increase	−0.05 (−0.419–0.319)	0.790	−0.147 (−527–0.233)	0.449
ORR
Any autoantibody
Negative	1 (reference)		1 (reference)
Positive	−0.693 (−2.810–1.424)	0.521	−0.107 (−0.443–0.229)	0.533
ANA
<1:80 (negative)	1 (reference)		1 (reference)
≥1:80 (positive)	−0.067 (−0.395–0.261)	0.688	0.078 (−0.241–0.398)	0.631
ANA titer change
No increase	1 (reference)		1 (reference)
Increase	−0.033 (−0.382–0.315)	0.851	0.042 (−0.307–0.391)	0.813

Abbreviations: ANA, antinuclear antibody; CI, confidence interval; DCR, disease control rate; ORR, objective response rate; RD, risk difference.