Table 2.
Association between prognostic factors and clinical deterioration with NEC in our institution.
| Variables | Clinical outcomes | OR (95% CI) | p-value | |
|---|---|---|---|---|
| Worsened (N, %) | Improved (N, %) | |||
| Age at onset (days) | < 0.001* | |||
| ≥ 10.5 | 29 (38.2) | 47 (61.8) | 2.63 (1.6–4.32) | |
| < 10.5 | 20 (14.5) | 118 (85.5) | ||
| History of PRC transfusion | 0.017* | |||
| Yes | 33 (29.5) | 79 (70.5) | 2.25 (1.15–4.39) | |
| No | 16 (15.8) | 86 (84.2) | ||
| Leukocyte count (/mm3) | 0.073 | |||
| ≥ 12,200 | 27 (28.7) | 67 (71.3) | 1.57 (0.96–2.57) | |
| < 12,200 | 22 (18.3) | 98 (81.7) | ||
| Platelet count (/mm3) | 0.001* | |||
| ≤ 79,500 | 27 (35.1) | 50 (64.9) | 2.18 (1.34–3.56) | |
| > 79,500 | 22 (16.1) | 115 (83.9) | ||
| CRP (mg/L) | < 0.001* | |||
| ≥ 4.5 | 40 (36.4) | 70 (63.6) | 4.2 (2.15–8.23) | |
| < 4.5 | 9 (8.7) | 95 (91.3) | ||
| Gestational age | 0.274 | |||
| Extremely preterm | 1 (7.1) | 13 (92.9) | 0.22 (0.03–1.78) | |
| Very preterm | 16 (21.3) | 59 (78.3) | 0.79 (0.39–1.56) | |
| Moderate to late preterm | 32 (25.6) | 93 (74.4) | ||
| Birth weight | 0.637 | |||
| ELBW | 12 (30) | 28 (70) | 2.14 (0.41–11.29) | |
| VLBW | 15 (20.3) | 59 (79.7) | 1.27 (0.25–6.43) | |
| LBW | 20 (22.7) | 68 (77.3) | 1.47 (0.29–7.27_ | |
| NBW | 2 (16.7) | 10 (83.3) | ||
*, p < 0.05; CI, confidence interval, OR odds ratio, NEC necrotizing enterocolitis, PRC packed red cell, CRP C-reactive protein, NBW normal birth weight, LBW low birth weight, VLBW very low birth weight, ELBW extremely low birth weight.