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. 2022 Aug 17;6:57. doi: 10.1038/s41698-022-00299-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Differential expression analysis was performed on the PDX tumor epithelial cell (human) and microenvironment (mice) matrices to evaluate the master regulators (MR) enrichment and pathways polarization. b Cox regression analysis confirmed the PDX transcriptional homology scoring significantly the patients following the MR-Gradient (uHR = 0.6, 95% CI [0.47–0.77]; P = 0.00005). In addition, we implemented ICA on the PDX expression matrix to identify the biological component that explains the MR-Gradient. c PDX ICA2 captured key pathways related with PDAC prognosis, including the tumor epithelial cell with the BAILEY_PROGENITOR (NES = 3.1; FDR = 0.0005), BAILEY_SQUAMOUS (NES = −3.6; FDR = 0.003) frame and microenvironment with I_CAF (NES = −2.17; FDR = 0.001), and MOFFITT_ACTIVATED_STROMA (NES = −1.63; FDR = 0.009). d Human and PDX ICA components displayed a high homology globally (r = 0.74; P < 0.0001) and both in tumor epithelial cell (r = 0.79; P < 0.0001) and microenvironment (r = 0.62; P < 0.0001) stratum, assigning equivalent weight to central PDAC biological markers. e Comparing gene contribution of human and PDX ICA components related with prognosis-related phenotype.