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. 2022 Aug 17;6:57. doi: 10.1038/s41698-022-00299-z

Fig. 5. Identification of key epigenetic modifiers related with the PDAC prognosis phenotype.

Fig. 5

a One hundred forty-nine chromatin modifiers correlated with the MR-Gradient at transcriptional level. Specifically, SUV39H1/H2 and KAT2B, two antagonist writers of the H3K9 residue were identified correlating negatively and positively with the MR-Gradient, respectively. b KAT2B displayed a shallow deletion in the 25% of PDX which was associated with a high-risk phenotype (P = 0.01). Moreover, KAT2B expression levels were modulated by the balance between the shallow deletion and the methylation profile. c KAT2B shallow deletion was confirmed in the TCGA-PAAD cohort and was significantly associated with a hypermethylation in the high-risk patients and 3p status. Error bars indicate mean ± SD. *P < 0.05. d Immunofluorescence analysis of H3K9me3, H3K9ac, H3K4me3 and H3K27ac, confirmed the polarization of SUV39H1/H2 and KAT2B into the MR-Gradient.