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. 2022 Aug 17;6:57. doi: 10.1038/s41698-022-00299-z

Fig. 7. MR-Gradient capture key metabolic features associated with PDAC prognosis.

Fig. 7

a Correlation between the lipid subfamilies and MR-Gradient, identified the glycerophospholipids (r = 0.36; P = 0.002), sphingolipids metabolites (r = −0.26; P = 0.02), and triacyclglycerols (r = −0.26; P = 0.03) as determinant of PDAC prognosis. b Principal component analysis (PCA) on the high correlated metabolites from the prognosis-related lipid subfamilies, showed that the dimension 1 (Dim 1; uHR = 0.9, 95% CI [1.01–1.18]; P = 0.03) explains the prognosis and confirms the lipid metabolism as key prognosis determinant through the glycerophospholipids, sphingolipids metabolites, and triacyclglycerols. c GATA6 and VIMENTIN were associated with the MR-Gradient. Furthermore, the lipid droplet marker, PLIN2 and the sphingosine modifier, SPHK1, showed higher expression levels in the high-risk than the low-risk PDX. d Glucose consumption and lactate production showed highest levels in the high-risk PDX. Concomitantly, the glutamine metabolism was higher in the high-risk PDX. Error bars indicate mean ± SD. *P < 0.05, **P < 0.01.