Table 1.
Baseline characteristics of patients with MAFLD and MAFLD-HCC.
| Characteristic | HCC (n = 135) | Non-HCC (n = 135) | p |
|---|---|---|---|
| Age (years) | 57.26 ± 12.59 | 59.52 ± 13.69 | 0.159 |
| Sex | |||
| Male | 82 (60.7%) | 74 (54.8%) | 0.324 |
| Female | 53 (39.3%) | 61 (45.2%) | |
| Cirrhosis | 26 (19.3%) | 0 (0%) | - |
| Prediabetes | 46 (34.1%) | 30 (22.2%) | 0.030 |
| Type II diabetes | 31 (23.0%) | 23 (17.0%) | 0.224 |
| Prediabetes or Type II diabetes | 77 (57.0%) | 53 (39.3%) | 0.003 |
| waist circumference(cm) | |||
| Male | 93.16 ± 14.56 | 97.58 ± 15.91 | 0.072 |
| Female | 85.11 ± 16.11 | 81.82 ± 16.66 | 0.287 |
| BMI | 24.50 ± 2.96 | 24.96 ± 3.31 | 0.229 |
| BMI ≥ 23 kg/m2 | 110 (81.5%) | 75 (55.6%) | < 0.001 |
| Hypertension | 74 (54.8%) | 48 (35.6%) | 0.001 |
| Dyslipidemia | |||
| Dyslipidemia | 91 (67.4%) | 61 (45.2%) | < 0.001 |
| HDL < 1.0 mmol/L | 64 (47.4%) | 45 (33.3%) | 0.018 |
| Triglycerides ≥ 1.7 mmol/L | 62 (45.9%) | 48 (35.6%) | 0.083 |
| Albumin (g/L) | 39.4 ± 6.94 | 41.36 ± 3.78 | 0.002 |
| Bilirubin (μmol/L) | 17.1[10.7, 39.9] | 13.2 [10.2, 16.9] | < 0.001 |
| ALT (U/L) | 39.0 [25.0, 63.0] | 24.0 [16.0, 40.0] | < 0.001 |
| AST (U/L) | 35.0 [26.0, 59.0] | 23.0 [19.0, 29.0] | < 0.001 |
| PLT (109/L) | 214.33 ± 92.03 | 218.46 ± 60.18 | 0.663 |
| CRP (mg/L) | 16.03 ± 12.89 | 4.93 ± 4.86 | < 0.001 |
| CRP > 2 mg/L | 125 (92.6%) | 102 (75.6%) | < 0.001 |
| FIB-4 | 2.49 ± 2.37 | 1.50 ± 0.92 | < 0.001 |
| FIB-4 > 1.3 | 91 (67.4%) | 82 (60.7%) | 0.254 |
| FIB-4 ≥ 2.67 | 38 (28.1%) | 8 (5.9%) | < 0.001 |
BMI body mass index, HDL high-density lipoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, PLT platelet, CRP hypersensitive C-reactive protein, FIB-4 fibrosis-4.