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. 2022 Aug 17;13(8):715. doi: 10.1038/s41419-022-05132-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Uniform Manifold Approximation and Projection (UMAP) plot of patients with non-atrophic gastritis (NAG), chronic atrophic gastritis (CAG), wild intestinal metaplasia (IMW), severe intestinal metaplasia (IMS) and EGC in GSE134520 are denoted by distinct colors. B UMAP plot showed the distribution of epithelial cells in patients with NAG, CAG, IMW, IMS and EGC, marked by the expression of marker gene epithelial cell adhesion molecule (EPCAM) (yellow, high; purple, low). C Differentially expressed genes in epithelial cells between patients with EGC and NAG (the significantly expressed gene, NDUFA4, is highlighted). D UMAP plot of NDUFA4 expression in patients with NAG, CAG, IMW, IMS and EGC (yellow, high; purple, low). E NDUFA4 expressionin epithelial cells between patients with EGC and NAG. F, G NDUFA4 expression in paired gastric and adjacent normal tissues in hospital cohort (F) and GSE33335 dataset (G). H Survival analysis and comparison among people with high and low values of NDUFA4 expression in GSE22377 database. I Representative IHC images and (J) scores of NDUFA4 in GC tissue microarrays. Scale bar: 100 μm. K Survival analysis and comparison among people with high and low expression of NDUFA4 expression in GC tissue microarrays. L The relative mRNA and protein levels of NDUFA4 in various GC cells and normal human gastric epithelium. *P < 0.05, ***P < 0.001 vs adjacent-normal or GES-1.