Table 3.
Top 3 similarity matches from an unsupervised search of the BioMAP Reference Database of >4,000 agents for each concentration of OXS007464
| Dose | Database match | BioMap Z-standard | Pearson’s Score | # of common biomarkers | Mechanism Class |
|---|---|---|---|---|---|
| 800 nM | Colchicine 1.1 μM | 17.479 | 0.896 | 148 | Microtubule Disruptor |
| Fosbretabulin Disodium 1.1 μM | 17.247 | 8.892 | 148 | Microtubule Disruptor | |
| Fosbretabulin Disodium 3.3 μM | 17.157 | 0.891 | 148 | Microtubule Disruptor | |
| 200 nM | Fosbretabulin Disodium 3.3 μM | 19.495 | 0.924 | 148 | Microtubule Disruptor |
| Fosbretabulin Disodium 10 μM | 19.257 | 0.922 | 147 | Microtubule Disruptor | |
| Fosbretabulin Disodium 30 μM | 19.188 | 0.921 | 148 | Microtubule Disruptor | |
| 50 nM | GSK46136A, 370nM | 16.977 | 0.877 | 148 | PLK1 inhibitor |
| Vincristine Sulfate, 14 nM | 16.926 | 0.877 | 148 | Microtubule Disruptor | |
| Pironectin, 14 nM | 16.486 | 0.881 | 146 | Microtubule Disruptor | |
| 12 nM | Erastin, 370nM | 5.678 | 0.496 | 112 | VDAC2 Blocker |
| SR-2640, 30 μM | 4.851 | 0.392 | 140 | Leukotriene | |
| Bemegride, 32 μM | 4.364 | 0.428 | 94 | GABA-A Receptor Antagonist |
The similarity between agents is determined using a combinatorial approach that accounts for the characteristics of BioMAP profiles by filtering (Tanimoto metric) and ranking (BioMAP Z-Standard) the Pearson’s correlation coefficient between two profiles. Profiles are identified as having mechanistically relevant similarity if the Pearson’s correlation coefficient is ≥0.7.