Table 4.

Top 3 similarity matches from an unsupervised search of the BioMAP Reference Database of >4,000 agents for each concentration of OXS007417

Dose	Database match	BioMap Z-standard	Pearson’s Score	# of common biomarkers	Mechanism Class
800 nM	Pironetin, 14 nM	18.362	0.911	146	Microtubule Disruptor
	Pironetin, 41 nM	17.424	0.897	146	Microtubule Disruptor
	Epothilone B, 37 nM	17.402	0.895	148	Microtubule Disruptor
200 nM	Pironetin, 14 nM	21.666	0.948	146	Microtubule Disruptor
	Epothilone B, 37 nM	20.508	0.936	148	Microtubule Disruptor
	Epothilone B, 12 nM	19.731	0.927	148	Microtubule Disruptor
50 nM	Paroxetine Hydrochloride, 14 μM	7.380	0.639	98	SERT Antagonist
	Nifedipine, 14 μM	6.934	0.612	98	L-type Ca++ Channel Antagonist
	TMP-153, 370 μM	6.926	0.519	148	ACAT Inhibitor
12 nM	Droperidol, 14 nM	4.935	0.388	148	Dopamine R Antagonist
	Fludrortisone, 14 nM	4.739	0.376	147	GR Agonist
	Sunitinib Malate, 14nM	4.577	0.363	148	VEGFR2 Inhibitor

The similarity between agents is determined using a combinatorial approach that accounts for the characteristics of BioMAP profiles by filtering (Tanimoto metric) and ranking (BioMAP Z-Standard) the Pearson’s correlation coefficient between two profiles. Profiles are identified as having mechanistically relevant similarity if the Pearson’s correlation coefficient is ≥0.7.