Table 6.

Molecular docking scores for curcumin, CCA-1.1, and PGV-1 against wild-type and mutant EGFR.

Drug	Protein	Binding Energy (kcal/Mol)	No of H bonds	Interacting amino acids (Distance)
Curcumin	EGFR (wild-type)	−11.05	1	Gln684 (2.97)
	EGFR (E709K)	−11.74	3	Gly696 (2.21), Pro699 (3.08), Asn700 (3.44)
	EGFR (T263P)	−10.12	2	Arg686 (2.98), Glu736 (3.19)
	EGFR (V774M)	−11.94	2	Asn298 (1.84), Arg831 (2.13)
	EGFR (L861Q)	−10.51	2	Arg297 (1.92), Leu707 (3.00)
CCA-1.1	EGFR (wild-type)	−12.51	2	Arg53 (1.80), Glu687 (1.79)
	EGFR (E709K)	−11.02	3	Val30 (2.04), Met54 (3.76), Arg297 (1.93)
	EGFR (T263P)	−11.29	1	Tyr299 (2.02)
	EGFR (V774M)	−10.91	1	Val30 (2.09)
	EGFR (L861Q)	−12.62	1	Val689 (3.13)
PGV-1	EGFR (wild-type)	−13.87	1	Arg686 (1.84)
	EGFR (E709K)	−10.73	1	Leu777 (2.29)
	EGFR (T263P)	−10.37	–	–
	EGFR (V774M)	−10.58	1	Leu861 (3.09)
	EGFR (L861Q)	−11.82	2	Phe723 (2.12), Lys875 (2.85)