Table 5.

Statistical significance for T0, T4 pairwise comparisons within each group by using sign test (pairwise_sign_test(), {rstatix} package).

Groups	n1	n2	df	p	p.adj
I	30	30	16	< 0.001	< 0.001
II			16	< 0.001	< 0.001
III			15	< 0.001	< 0.001
IV			8	0.008	0.008
K			27	< 0.001	< 0.001

n1, n2 sample counts for T0, T4 respectively, df the total number of differences (degrees of freedom), p p-value, p.adj -value adjusted by “holm” method.