Fig. 1.

Study design. ^aThere was no controlled product use period on day − 1; participants completed the ad libitum use period followed by overnight abstinence on day − 1. The participants stayed in the clinic for a total of 8 days (day − 1 through day 7). ^bThere was no afternoon ad libitum use period after the controlled use period in the morning on the last study day, day 7. DEP, Direct Effects of Product Questionnaire; mCEQ, Modified Cigarette Evaluation Questionnaire; MST, moist smokeless tobacco; NP, nicotine pouch; OBC, own brand cigarette; QSU, Questionnaire on Smoking Urges; TNW, Tobacco/Nicotine Withdrawal Questionnaire