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. 2022 Aug 17;12:13970. doi: 10.1038/s41598-022-18232-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Unsupervised hierarchical cluster heatmap of the significant differentially methylated loci of the repetitive elements in non-ASD and ASD. Clustering of the 7165 significant differentially methylated loci (combining of LINE-1 and Alu loci) (a). Clustering of the 2802 significant differentially methylated loci (LINE-1) (b). Clustering of the 4363 significant differentially methylated loci (Alu) (c). The color scale indicates methylation level (M value), from low (blue) to high (red). Green color represents ASD and white color represents non-ASD.