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. 2022 Aug 17;13(8):716. doi: 10.1038/s41419-022-05160-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Puromycin levels were increased in the DDp53 electroporated tibialis anterior muscle compared to the contralateral control leg. B Simultaneously, phospho-S6K1 (Thr389) levels were significantly decreased in the DDp53 leg. C At the same time, downstream target phospho-rS6 (Ser240/244) was unchanged between the legs. D Phospho-eEF2 (Thr56) was significantly decreased after DDp53 electroporation compared to the control. Individual data points represent the results from each animal. Squares represent the leg that was electroporated with DDp53, circles the contralateral control leg of the same animals. Western blot images show three representative bands from each condition. Both representative pictures stem from the same membrane and exposure time. All western blots were normalized to total protein per lane. Original, unaltered images of all membranes and the gels that they were normalized to can be found in the data supplement. n = 12, * indicates a p-value of <0.05, ** indicates a p-value of <0.01 and **** indicates a p-value of <0.0001.