Table 2.
Pharmacokinetic parameters of xanthorrhizol after oral administration of xanthorrhizol (15 mg/kg) and a Java turmeric supercritical extract (200 mg/kg; 60 mg/kg as xanthorrhizol) in rats (mean ± SD, n = 5)
| Parameter | Intravenousa | Oral | |
|---|---|---|---|
| Xanthorrhizol (5 mg/kg) | Xanthorrhizol (15 mg/kg) | Supercritical extract (200 mg/kg) | |
| AUCinf (ng h/mL) | 229 ± 28 | 92 ± 5 | 353 ± 165 |
| Cmax (ng/mL) | – | 18 ± 8 | 55 ± 22 |
| Tmax (h) | – | 0.4 ± 0.2 | 2.2 ± 0.5 |
| t1/2 (h) | 5.6 ± 0.5 | 7.5 ± 0.3 | 5.6 ± 4.1 |
| CL (L/h/kg) | 19.1 ± 2.3 | 21.0 ± 1.1b | 22.8 ± 10.5b |
| F (%) | – | 12.9 | 13.4 |
aThe data were retrieved from our previous work (Choi et al., 2017)
bBioavailability was taken into account
AUCinf, area under the plasma concentration time to infinite; Cmax, maximum concentration; Tmax, time-to-Cmax; t1/2, half-life; CL, clearance; F(%), bioavailability