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PRPP inhibition of PurR binding to the purA control region DNA. The effect of PRPP on binding is shown for wild-type PurR (■) and two mutants, PurR D203A (●) and D204A (▴). The fraction of DNA bound to PurR in the absence of PRPP (0.82 for wild type, 0.81 for D203A, and 0.89 for D204A) was normalized to 1.0. The apparent Kd values for binding to operator DNA for the wild type and the mutants were similar.
