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. 2022 Aug 17;12:13913. doi: 10.1038/s41598-022-17791-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RET mRNA levels and methylation in TCGA cancers. (A) RET mRNA levels (log2 TPM transformed) between tumor tissues and the paired normal tissues among diverse TCGA cancers from TIMER2. (B) Bubble map illustrating the differences of RET and related downstream genes methylation between tumor tissues and corresponding normal tissues among cancers. Red dot: the upregulation of methylation in indicated cancers, blue dot: the downregulation of methylation in indicated cancers. (C) Bubble map depicting the relation between methylation and RET and its downstream genes expression in different TCGA cancers. Red dot: the increases in both methylation level and gene expression level, blue dot: the increase in methylation level but decrease in gene expression level. TPM transcripts per million. *p < 0.05, **p < 0.01, ***p < 0.001.