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. 2022 Aug 4;13:958368. doi: 10.3389/fimmu.2022.958368

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Copyright © 2022 Song, Zhou, Shu and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different clinical and TME features of the two cuproptosis subtypes in BLCA. (A) Heatmap depicts the correlation between the subtypes and different clinicopathological characteristics. (B) GSVA enrichment analysis of biological pathways between the two distinct subtypes. (C) Boxplots show variations in mRNA expression of HLAs in the two cuproptosis subtypes. (D) Boxplots show abundance of 23 infiltrating immune cell types and differences in immune scores in the two cuproptosis subtypes. (E) Representative pictures of pathological H&E staining of two cuproptosis subtypes (*p < 0.05; **p < 0.01; ***p < 0.001; Ns, not significant). TME, tumor microenvironment; BLCA, bladder cancer; GSVA, gene set variation analysis; HLAs, human leukocyte antigens.