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. 2022 Aug 4;13:958368. doi: 10.3389/fimmu.2022.958368

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Copyright © 2022 Song, Zhou, Shu and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development and validation of the cuproptosis scoring system for BLCA. (A) Alluvial diagram of two cuproptosis subtypes, four gene clusters, cuproptosis scores, and clinical outcomes. Differences in cuproptosis score between (B) the two cuproptosis subtypes and (C) the four gene clusters. (D) Kaplan–Meier analysis of the OS between the two cuproptosis score groups. (E) ROC curves to predict the sensitivity and specificity of 1-, 3-, and 5-year survival according to the cuproptosis score. (F) Histogram and (G) boxplot depict the distribution of survival status of BLCA patients in the two groups. (H) Clinical characteristics for the high and low cuproptosis score groups. BLCA, bladder cancer; OS, overall survival; ROC, receiver operating characteristic.