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Localization of systemic highly pathogenic avian influenza (HPAI) infection versus low pathogenic avian influenza (LPAI) infection in chicken and duck. In chickens, proteases in gut and respiratory systems enable LPAI and HPAI replication while in ducks, their gut is the primary organ for LPAI replication and shedding and respiratory tract is the main site for HPAI replication and shedding.
