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. 2022 Aug 4;9:922534. doi: 10.3389/fcvm.2022.922534

FIGURE 5.

FIGURE 5

Ferroptosis presented in LPS-induced SCD mice. (A) Survival curve of WT mice intraperitoneally injected with either PBS or Fer-1 (1 mg/kg) at 24 h, 2 h before LPS (25 mg/kg, n = 10 in each group) administration. (B,C) Echocardiography was performed in WT mice intraperitoneally injected with either PBS or Fer-1 (1 mg/kg) at 24 h, 2 h followed by LPS (25 mg/kg) or PBS administration for 12 h (n = 4, 6, 6, 4, respectively). (D) Invasive hemodynamics was monitored in WT mice intraperitoneally injected with either PBS or Fer-1 (1 mg/kg) at 24 h, 2 h followed by LPS (25 mg/kg) or PBS administration for 12 h (n = 6 in each group). (E) Cardiac MDA levels were detected in WT mice intraperitoneally injected with either PBS or Fer-1 (1 mg/kg) at 24 h, 2 h followed by LPS (25 mg/kg) or PBS administration for 12 h (n = 4 in each group). (F) Cardiac PTGS2 mRNA expressions were determined by qPCR in WT mice intraperitoneally injected with either PBS or Fer-1 (1 mg/kg) at 24 h, 2 h followed by LPS (25 mg/kg) or PBS administration for 12 h (n = 9 in each group). (G) Cardiac MDA levels were detected in LCN2 KO mice and their WT littermates 12 h after intraperitoneal injection of either PBS or LPS (25 mg/kg) (n = 7 in each group). *p < 0.05, **p < 0.01, ***p < 0.001.