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. 2022 Aug 4;13:887833. doi: 10.3389/fphar.2022.887833

FIGURE 4.

FIGURE 4

PD could reduce OHCs loss after cisplatin administration. (A) The cochlea of guinea pigs was divided into 4 turns, and the basilar membrane was dissected from them, and then stained and counted. Scale bar, 50 μm. (B) In turn 1, only the 40 mg/kg PD + CDDP group could improve the survival rate of OHCs compared with that of the CDDP group, p = 0.001. (C), (D) and (E) In turn 2, turn 3, and turn 4, compared with the CDDP group, both 20 mg/kg PD + CDDP and 40 mg/kg PD + CDDP groups could improve the survival rate of OHCs, and the 40 mg/kg PD + CDDP group presented a better protective effect on OHCs than that of the 20 mg/kg PD + CDDP group (p = 0.003, p < 0.001 and p = 0.002 for turn 2, turn 3 and turn 4, respectively). (F) Graph shows the survival rate of OHCs after drug administration in each group. Either cisplatin or PD, the survival rate of OHCs always increases gradually from turn 1 to turn 4. n = 5. Data are presented as mean ± SEM. **p < 0.01, and ***p < 0.001, all versus the CDDP group.