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. 2022 Aug 4;13:887833. doi: 10.3389/fphar.2022.887833

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Copyright © 2022 Li, Zhao, Xu, Lin, Zhao, Li, Cui and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD increases the antioxidant capacity of cochlea after cisplatin administration. Representative immunofluorescence labelling in the cochlea for Nrf2 (green, (A) and HO-1 (green, (B), double stained with DAPI in blue. The three dotted areas are SGNs, OHCs and SV. (A) and (B) In the control group, Nrf2 and HO-1 were slightly expressed in SGNs, OHCs and SV. After cisplatin administration, Nrf2 translocation into the nucleus was increased, along with the increased expression of Nrf2 and HO-1, and the green fluorescence intensity was slightly increased. The expression of Nrf2 and HO-1 was increased by PD and DEX before cisplatin administration, and the green fluorescence intensity was higher than that of CDDP group. Scale bar, 100 μm.