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. 2022 Aug 4;13:930278. doi: 10.3389/fimmu.2022.930278
RA rheumatoid arthritis
TCA cycle tricarboxylic acid cycle
NSAIDs non-steroidal anti-inflammatory drugs
FLS fibroblast-like synoviocytes
FDX1 ferredoxin 1
LIAS lipoic acid synthetase
LIPT1 lipoyltransferase 1
DLD dihydrolipoamide dehydrogenase
DLAT drolipoamide S-acetyltransferase
PDHA1 pyruvate dehydrogenase E1 subunit alpha 1
PDHB pyruvate dehydrogenase E1 subunit beta
MTF1 metal-regulatory transcription factor-1
GLS glutaminase
CDKN2A cyclin-dependent kinase inhibitor 2A
MMPs matrix metallopeptidases
IL interleukin
CCL20 chemokine (C-C motif) ligand 20
FoxO3 forkhead box O-3
PDHC the pyruvate dehydrogenase (PDH) complex
ATP adenosine triphosphate
RUNX2 RUNX family transcription factor 2
PKB phosphorylated protein kinase B
HK2 hexokinase 2
PDHK1 PDH kinases 1
SIRT6 sirtuin 6
PI3K phosphatidylinositol 3−kinase
AKT protein kinase B
ERK the extracellular signal-regulated kinase
NF-κ;B nuclear factor-κ;B
TNFα tumor necrosis factor α
NLRP3 the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3
MEG3 maternally expressed gene 3
miR miRNA
GRP78 glucose-regulated protein 78
ATF6 activating transcription factor 6
CHOP C/EBP homologous protein
NEK10 NIMA-related kinase 10
IFN-γ interferon γ
CCR6 chemokine (C-C motif) receptor 6
CXCR3 C-X-C chemokine receptor 3
PPAR-γ peroxisome proliferator- activated receptor γ
2-HG 2-hydroxyglutarate
KDM5 lysine demethylase 5
H3K4me3 trimethylation of Histone H3 at Lysine 4
ROS reactive oxygen species
RORγt retinoic acid-related orphan receptor γt
E4F1 E4 transcription factor 1
SIRT4 sirtuin 4
anti-CCP the antibodies cyclic citrullinated peptides
ESR erythrocyte sedimentation rate
CRP C-reactive protein
C1QBP component 1 q subcomponent-binding protein
Fe/S iron-sulfur
RANKL receptor activator of nuclear factor κ-B ligand
NADPH nicotinamide adenine dinucleotide phosphate
CYP11A1 cytochrome P450 11A1
MRE metal responsive element
PIGF phosphatidylinositol glycan anchor biosynthesis class F
HIF-1 hypoxia-inducible factor-1
FOXP3 forkhead box P3
PHDs prolyl hydroxylases
ox-LDL oxidized low-density lipoprotein
NKR natural killer receptors