RA |
rheumatoid arthritis |
TCA cycle |
tricarboxylic acid cycle |
NSAIDs |
non-steroidal anti-inflammatory drugs |
FLS |
fibroblast-like synoviocytes |
FDX1 |
ferredoxin 1 |
LIAS |
lipoic acid synthetase |
LIPT1 |
lipoyltransferase 1 |
DLD |
dihydrolipoamide dehydrogenase |
DLAT |
drolipoamide S-acetyltransferase |
PDHA1 |
pyruvate dehydrogenase E1 subunit alpha 1 |
PDHB |
pyruvate dehydrogenase E1 subunit beta |
MTF1 |
metal-regulatory transcription factor-1 |
GLS |
glutaminase |
CDKN2A |
cyclin-dependent kinase inhibitor 2A |
MMPs |
matrix metallopeptidases |
IL |
interleukin |
CCL20 |
chemokine (C-C motif) ligand 20 |
FoxO3 |
forkhead box O-3 |
PDHC |
the pyruvate dehydrogenase (PDH) complex |
ATP |
adenosine triphosphate |
RUNX2 |
RUNX family transcription factor 2 |
PKB |
phosphorylated protein kinase B |
HK2 |
hexokinase 2 |
PDHK1 |
PDH kinases 1 |
SIRT6 |
sirtuin 6 |
PI3K |
phosphatidylinositol 3−kinase |
AKT |
protein kinase B |
ERK |
the extracellular signal-regulated kinase |
NF-κ;B |
nuclear factor-κ;B |
TNFα |
tumor necrosis factor α |
NLRP3 |
the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 |
MEG3 |
maternally expressed gene 3 |
miR |
miRNA |
GRP78 |
glucose-regulated protein 78 |
ATF6 |
activating transcription factor 6 |
CHOP |
C/EBP homologous protein |
NEK10 |
NIMA-related kinase 10 |
IFN-γ |
interferon γ |
CCR6 |
chemokine (C-C motif) receptor 6 |
CXCR3 |
C-X-C chemokine receptor 3 |
PPAR-γ |
peroxisome proliferator- activated receptor γ |
2-HG |
2-hydroxyglutarate |
KDM5 |
lysine demethylase 5 |
H3K4me3 |
trimethylation of Histone H3 at Lysine 4 |
ROS |
reactive oxygen species |
RORγt |
retinoic acid-related orphan receptor γt |
E4F1 |
E4 transcription factor 1 |
SIRT4 |
sirtuin 4 |
anti-CCP |
the antibodies cyclic citrullinated peptides |
ESR |
erythrocyte sedimentation rate |
CRP |
C-reactive protein |
C1QBP |
component 1 q subcomponent-binding protein |
Fe/S |
iron-sulfur |
RANKL |
receptor activator of nuclear factor κ-B ligand |
NADPH |
nicotinamide adenine dinucleotide phosphate |
CYP11A1 |
cytochrome P450 11A1 |
MRE |
metal responsive element |
PIGF |
phosphatidylinositol glycan anchor biosynthesis class F |
HIF-1 |
hypoxia-inducible factor-1 |
FOXP3 |
forkhead box P3 |
PHDs |
prolyl hydroxylases |
ox-LDL |
oxidized low-density lipoprotein |
NKR |
natural killer receptors |