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. 2022 Aug 13;17:3603–3618. doi: 10.2147/IJN.S372254

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© 2022 Lu et al.

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Therapeutic efficacy of MSC-Exo in acute kidney injury.

Notes: Sham+Veh: Sham group treated with vehicle; Sham+Exo: Sham group treated with MSC-Exo; I/R+Veh: Ischemia-reperfusion model treated with vehicle; I/R+Exo: Ischemia-reperfusion model treated with MSC-Exo. (A) Kidney tissue hematoxylin and eosin (HE) staining in four groups. Scale bar = 100 µm. Injured tubules with intraluminal casts are indicated by arrows. (B) NGAL immunohistochemical staining. Scale bar = 100 µm. MSC-Exo administration caused significant relief in interstitial edema, tubular dilatation, vacuolar degeneration, and necrosis. Immunohistochemistry showed a decrease in NGAL expression after treatment. Reproduced with permission from Huang J, Cao H, Cui B et al. Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model. Front Cell Dev Biol. 2022;10:899869.⁴⁹ Copyright © 2022 The Authors. Creative Commons Attribution License.

Abbreviations: MSC-Exo, Mesenchymal Stem Cell-derived exosome; NGAL, Neutrophil gelatinase-associated lipocalin.