Table 4.

Clinical and histological predictors of KFI (univariate and multivariate analysis)

	Univariate analysis			Multivariate analysis 1			Multivariate analysis 2
	OR	CI	P	OR	CI	P	OR	CI	P value
Histological features at first kidney biopsy
Cellular/fibrocellular crescents>1*	5.805	1.275 to 26.441	0.023
Clinical features at second kidney biopsy
Serum creatinine	1.329	1.123 to 1.572	0.001
Proteinuria>3.5 g/die	3.239	1.457 to 7.197	0.004
Arterial hypertension	3.384	1.374 to 8.337	0.008
Histological features at second kidney biopsy
Activity Index >3	3.808	1.516 to 9.564	0.004	3.230	1.275 to 8.183	0.013
Cell/fibrocell crescents>1*	4.141	1.406 to 12.199	0.010				4.207	1.416 to 12.500	0.010
Hyaline deposits>1*	2.836	1.216 to 6.614	0.016
Chronicity Index>4	3.476	1.544 to 7.824	0.003	2.905	1.285 to 6.566	0.010
Fibrous crescents>1*	2.902	1.148 to 7.335	0.024
Interstitial fibrosis >1*	2.498	1.114 to 5.598	0.026				2.525	1.120 to 5.691	0.025

*These variables were categorised as: 0+1 vs 2+3, being: 0 if absent; 1+ if mild (in less than 25% of glomeruli and/or in tubulointerstitial cortex); 2+ if moderate (in between 25% and less than 50% of glomeruli and/or in tubulointerstitial cortex) and 3+ if severe (in more than 50% of glomeruli and/or in tubulointerstitial cortex).

KFI, kidney function impairment.