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. 2022 Aug 16;9(1):e000857. doi: 10.1136/bmjgast-2021-000857

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Prevalence of prespecified comorbidities among (A) patients in the PBC population (N=1963) or (B) the PBC-pruritus subpopulation (N=139) relative to the respective non-case populations*. *Ns for the non-case population differs between analysis A and B: non-cases for analysis A (PBC population) N=10 245 592; non-cases for analysis B (PBC-pruritus subpopulation) N=9 984 009. Prevalence of prespecified comorbidities in the PBC population or the PBC-pruritus subpopulation, using prevalence in the non-case population as reference. iSPRs ˃1 imply greater prevalence in either of the PBC case populations versus the non-case population. Crude point prevalence (%) and iSPRs (95% CIs) for each of the comorbidities shown are also reported in table 1. iSPRs, indirect age-sex standardised prevalence ratios; PBC, primary biliary cholangitis; SLE, systemic lupus erythematosus; UTI, urinary tract infection.