Table 1.
Parameter values of agonist estradiol binding to estrogen receptors.
| Model | Parameters | Values |
|---|---|---|
|
| ||
| Two-state dimer | RT (nM) | 2.4 ± 0.1 |
| KDA1 (nM) | 3 ± 1 | |
| KDA2 (nM) | 0.2 ± 0.1 | |
| D C | 1.8 | |
Data for non-linear regression were taken from Fig. 1 and fitted assuming the two-state dimer receptor model. RT is the total amount of receptor dimers, KDA1 and KDA2 are, respectively, the equilibrium dissociation constants of the first and second binding of [3H]estradiol to a dimer. DC is the dimer cooperativity index for [3H]estradiol binding. Parameter values are mean ± s.e.m.