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. 2022 Aug 4;12:985470. doi: 10.3389/fonc.2022.985470

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Copyright © 2022 Yi, Han and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low miR-625 levels are associated with the malignant progression of endometrial cancer. (A) The miRNAs that might bind to circ_0007534 were predicted using the CircInteractome database. (B) The luciferase reporter plasmids contained wild-type (WT) and mutated (MUT) miR-625 binding sites in the circ_0007534 sequence. (C) Real-time PCR detection of miR-625 expression in endometrial cancer and normal tissues. (D-G) MiR-625 expression in endometrial cancer patients with different tumor grades (D), tumor stage (E), depth of invasion (F), and the presence (or absence) of lymph node metastasis (G) were explored using qRT-PCRs. (H) MiR-625 expression in endometrial cancer cells and normal cells. ***P < 0.001.