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. 2022 Aug 4;12:985470. doi: 10.3389/fonc.2022.985470

Figure 6.

Figure 6

Circ_0007534 sponges miR-625 to promote endometrial cancer cell proliferation and invasion. (A) MiR-625 expression in endometrial cancer cells transfected with miR-625 mimic or inhibitor. (B) Luciferase reporter assay of endometrial cancer cells transfected with miR-625 mimic, miR-625 inhibitor, and luciferase reporter plasmids containing WT or MUT circ_0007534. (C, D) The expression of miR-625 in HEC-1 cells after knockdown of circ_0007534 (C), or in Ishikawa cells after overexpression of circ_0007534 (D) was examined. (E) The proliferation of HEC-1 cells transfected with circ_0007534 shRNA, miR-625 inhibitor, or the respective controls (left). The proliferation of Ishikawa cells transfected with circ_0007534 vector, miR-625 mimic, or the respective controls (right). (F) The invasion of HEC-1 cells transfected with circ_0007534 shRNA, miR-625 inhibitor, or the respective controls (left). The invasion of Ishikawa cells transfected with circ_0007534 vector, miR-625 mimic, or the respective controls (right). ***P < 0.001.