Table 3.

Several common codons that are vulnerable to cellular stress leading to missense mutations (68).

Exon (Codon)	Missense mutation	Amino acid change
5 (175)	Guanine → Adenine	Arginine → Histidine
7 (245)	Guanine → Adenine	Glycine → Serine
	Guanine → Adenine	Glycine → Aspartic acid
7 (248)	Cytosine → Thymine	Arginine → Tryptophan
	Guanine → Adenine	Arginine → Glutamine
8 (273)	Cytosine → Thymine	Arginine → Cysteine
	Guanine → Adenine	Arginine → Histidine
8 (282)	Cytosine → Thymine	Arginine → Tryptophan