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. 2022 Aug 17;12(8):e940. doi: 10.1002/ctm2.940

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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AlkB homologue 5 (ALKBH5) was downregulated in colorectal cancer (CRC). (A) ALKBH5 mRNA expression in 23 solid cancers in The Cancer Genome Atlas (TCGA) databases. (B) ALKBH5 mRNA expression in CRC in the Gene Expression Omnibus (GEO) databases. (C) RT‐qPCR analysis of ALKBH5 mRNA expression in 24 paired CRC tumours and adjacent normal tissues. (D) Representative immunohistochemical staining (IHC) images of ALKBH5 expression in CRC tumour and paired normal tissues. (E) Quantification of the IHC score of ALKBH5 in CRC tumour tissues (n = 114) and adjacent normal tissues (n = 107). (F) Relative quantitative analysis of global N6‐methyladenosine (m⁶A) levels of mRNA in CRC tumour tissues and adjacent normal tissues. Statistical significance was determined using Wilcoxon test (A, B, E), paired Wilcoxon test (C) and t‐test (F) (^* p < .05, ^** p < .01).