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. 2022 Aug 17;12(8):e940. doi: 10.1002/ctm2.940

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Overexpression of alkB homologue 5 (ALKBH5) inhibited proliferation, migration and invasion of colon cancer cells in vitro. (A and B) ALKBH5 mRNA expression in LOVO (A) and RKO (B) cells infected with ALKBH5‐overexpression or control vector lentiviruses. (C) ALKBH5 protein expression in LOVO and RKO cells infected with ALKBH5‐overexpression or control vector lentiviruses. (D and E) The proliferation ability of LOVO and RKO with ALKBH5 knock‐down, as determined by CCK8 (D) and colony formation (E) assays. (F and G) The migration (F) and invasion (G) ability of LOVO and RKO cells with ALKBH5 knock‐down, as determined by transwell assays. Statistical significance was determined using t‐test (^* p < .05, ^** p < .01).