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. 2022 Aug 17;12(8):e945. doi: 10.1002/ctm2.945

FIGURE 8.

FIGURE 8

FAM135B facilitates DNA repair in vivo. (A) Schematic picture of mice IR assay. FAM135B transgenic (FAM135Btg) and wild‐type (WT) mice were used in this assay. In each group, one mouse was used as a negative control, five underwent 6‐Gy IR, and subsequently, mice were euthanised at the indicated time points and oesophagus tissues were taken for further immunohistochemistry (IHC) assay. (B) Representative IHC images of γpres for both FAM135Btg and WT mice, respectively. (C) Quantification of the γQuan IHC score. Five visual fields were analysed per sample. (D) Representative IHC images of FAM135B in patients with platinum‐based chemotherapy (left panel). Quantification of the FAM135B IHC score is shown in the right panel. *p < .05

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