Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 17;12(8):e995. doi: 10.1002/ctm2.995

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Blockage of the glucuronic pathway or TGFβ signalling blunts hepatocellular carcinoma (HCC) metastasis driven by Gstz1 loss. (A) Schematic representation of diethylnitrosamine (DEN) and CCl₄‐ induced mouse model of HCC. PB, phenobarbital. (B) Representative images of lung metastasis. (C) Hematoxylin‐and‐eosin (H&E) staining of occult metastases in lung tissue sections. Scale bar, 500 μm. (D) Number of lung metastases. Data represent mean ± SD of the relative number of nodules per mouse for six mice. (E) UDP‐GlcUA levels in mouse liver tissues. n = 6. (F) The relative content of UDP‐GlcUA normalized to the average UDP‐GlcUA level in serum samples obtained from Gstz1 ^+/+ mice . n = 6. (G) Hematoxylin‐and‐eosin (H&E) and Immunohistochemistry (IHC) staining for GSTZ1, UGDH, pSmad2/3 and Snail in WT and Gstz1⁻ ^/‐ mouse liver sections. NT, non‐tumour; T, tumour. Scale bar: 50 μm. Data are mean ± SD. p‐Values were derived from a one‐way ANOVA followed by the Tukey test in (D, E and F) (*p < .05, ***p < .001).