Table 1.

Effects of substituted group R¹ and R² on enzyme inhibition.

compound	R1	R2	% enzyme inhibition
			MDM2	HDAC
7a	H	Ph	39	69
7b	5-Me	Ph	45	71
7c	5-F	Ph	51	68
7d	5-Cl	Ph	49	67
7e	5-Br	Ph	48	72
7f	6-Cl	Ph	65	64
7g	6-Br	Ph	59	68
7h	7-Me	Ph	23	71
7i	7-Br	Ph	30	67
7j	5-OMe	Ph	50	70
7k	6-OMe	Ph	54	70
7l	H	3-OMe-C6H4	44	62
7m	H	4-NMe2-C6H4	40	68
7n	H	3-Br-C6H4	43	69
7w	6-Cl	3-OMe-C6H4	60	69
7x	6-Cl	4-F-C6H4	62	73
7y	6-Cl	4-NMe2-C6H4	54	71
15b	6-Cl	2-furyl	48	70
15c	6-Cl	2-thienyl	49	70