Table 6.
IC50 values of compound 11b against HDAC subtypes.
| Target | IC50(μM) a | Target | IC50(μM) a | ||
|---|---|---|---|---|---|
| 11b | SAHA | 11b | SAHA | ||
| HDAC1 | 0.058 ± 0.005 | 0.019 ± 0.004 | HDAC7 | >10 | >10 |
| HDAC2 | 0.064 ± 0.004 | 0.039 ± 0.007 | HDAC8 | 0.313 ± 0.023 | 0.183 ± 0.027 |
| HDAC3 | 0.115 ± 0.009 | 0.053 ± 0.006 | HDAC9 | >10 | >10 |
| HDAC4 | >10 | >10 | HDAC10 | 1.495 ± 0.037 | 0.379 ± 0.022 |
| HDAC5 | >10 | >10 | HDAC11 | >10 | >10 |
| HDAC6 | 0.120 ± 0.026 | 0.044 ± 0.005 | MDM2 | 0.339 ± 0.068 | ND |
a
IC50 = compound concentration required to inhibit tumor cell proliferation by 50%; Data displayed is the average of at least three independent replicates ± standard.