Fig. 5.

ARI and TRZ treatment caused a strong and significant increase of 7-DHC levels in all brain regions of C57BL/6 mice. Each symbol represents a regional brain sample from a single mouse. The x-axis denotes animal groups; y- axis denotes 7-DHC concentration normalized to mg of protein. Black asterisk denotes comparison with baseline levels. Two-tailed groupwise t test was used for statistical comparisons, ∗∗∗∗P<0.0001. Abbreviations: ARI, aripiprazole; TRZ, trazodone; ARI+TRZ, combined treatment with aripiprazole and trazodone. 7-DHC fold changes over vehicle treatment for each brain region are presented in supplemental Fig. S6A.