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. 2022 Aug 4;13:961554. doi: 10.3389/fgene.2022.961554

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Copyright © 2022 Dai, Wang, Bai, Liu, Chen, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a cellular senescence-related risk score signature. (A) LASSO regression analysis. (B) Cross-validation for tuning the parameter selection. (C) The PCA plot of the training set. (D) The PCA plot of the test set. (E) The t-SEN plot of the training set. (F) The t-SEN plot of the testing set. (G) The K-M survival curve of all colon cancer samples, p < 0.001. (H) The K-M survival curve of the training set, p < 0.001. (I) The Kaplan-Meier survival curve of the testing set, p < 0.001. (J) The AUC values of 1-year, 3-years, and 5-years survival for all colon cancer patients were more than 0.700. (K) The AUC values of 1-year, 3-years, and 5-years survival for the training set were more than 0.750. (L) The AUC values of 1-year, 3-years, and 5-years survival for the testing set were more than 0.600.